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| Rancho Mirage $25,000 Hard | Feb 7 2010 |
| Qual 1 | Spears(1) - Chihiro Takayama | 6-3 6-3 |
| Qual 2 | Spears(1) - Lindsey Nelson | 6-2 3-6 6-3 |
| Qual 3 | Spears(1) - Claire De Gubernatis(10) | 6-3 4-6 6-4 |
| 1 | Lilia Osterloh(1) - Spears | 6-4 6-4 |
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| Laguna Nigel $25,000 Hard | Feb 14 2010 |
| 1 | Spears(6) - Sloane Stephens | 6-0 6-2 |
| 2 | Spears(6) - Shuko Aoyama | 6-1 6-1 |
| QF | Olivia Sanchez - Spears(6) | 7-5 4-6 6-4 |
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| Surprise $25,000 Hard | Feb 21 2010 |
| 1 | Spears(8) - Olivia Sanchez | 7-5 6-3 |
| 2 | Spears(8) - Florencia Molinero | 6-1 6-0 |
| QF | Spears(8) - Anastasia Pivovarova(4) | 6-3 6-4 |
| SF | Spears(8) - Christina McHale(7) | 6-2 7-66 |
| F | Spears(8) - Kurumi Nara(3) | 6-1 6-2 |
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| Monterrey International Hard | Mar 7 2010 |
| Qual 1 | Spears - Kathrin Woerle-Scheller | 6-2 5-7 6-4 |
| Qual 2 | Maria-Fernanda Alves - Spears | 7-63 7-64 |
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| Indian Wells Premier Hard | Mar 21 2010 |
| Qual 1 | Pauline Parmentier(19) - Spears | 3-6 6-4 7-62 |
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| Ponte Vedra Beach International Clay | Apr 11 2010 |
| Qual 1 | Spears - Alison Riske | 6-2 7-5 |
| Qual 2 | Sesil Karatantcheva - Spears | 6-1 6-4 |
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| Charleston Premier Clay | Apr 18 2010 |
| Qual 1 | Galina Voskoboeva(5) - Spears | 6-2 6-2 |
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| Dothan $50,000 Clay | Apr 25 2010 |
| 1 | Spears - Julie Ditty | 7-65 7-63 |
| 2 | Spears - Michaella Krajicek(7) | 2-6 7-65 7-65 |
| QF | Spears - Jamie Hampton | 6-4 6-75 6-4 |
| SF | Anastasiya Yakimova(6) - Spears | 6-3 6-4 |
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| Warsaw Premier Clay | May 23 2010 |
| Qual 1 | Spears - Su-Wei Hsieh | 6-2 7-5 |
| Qual 2 | Greta Arn - Spears | 7-5 6-2 |
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| Nottingham $50,000 Grass | Jun 6 2010 |
| 1 | Spears - Jocelyn Rae | 4-6 6-3 6-2 |
| 2 | Noppawan Lertcheewakarn - Spears | 6-4 6-4 |
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| Eastbourne Premier Grass | Jun 20 2010 |
| Qual 1 | Spears - Renata Voracova(2) | 7-66 6-4 |
| Qual 2 | Karolina Sprem - Spears | 6-4 3-6 7-5 |
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| San Diego Premier Hard | Aug 8 2010 |
| Qual 1 | Spears - Ivana Lisjak | 6-4 6-3 |
| Qual 2 | Jamie Hampton - Spears | 7-66 6-3 |
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| Montreal Premier Hard | Aug 22 2010 |
| Qual 1 | Spears - Julia Cohen | 7-5 6-1 |
| Qual 2 | Jarmila Gajdosova(9) - Spears | 6-4 6-3 |
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| Quebec City International Carpet | Sep 19 2010 |
| Qual 1 | Spears - Séverine Beltrame | 5-7 6-4 6-3 |
| Qual 2 | Spears - Lindsay Lee-Waters | 6-75 6-4 6-3 |
| Qual 3 | Irina Falconi - Spears | 5-7 7-5 7-64 |
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| Albuquerque $75,000 Hard | Sep 26 2010 |
| 1 | Laura Siegemund - Spears | 7-5 5-7 6-3 |
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| Las Vegas $50,000 Hard | Oct 3 2010 |
| 1 | Spears - Laura Siegemund | 6-1 6-4 |
| 2 | Spears - Chelsey Gullickson | 6-0 5-7 6-4 |
| QF | Mirjana Lucic-Baroni(4) - Spears | 7-63 7-5 |
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| Kansas City $50,000 Hard | Oct 10 2010 |
| 1 | Edina Gallovits-Hall(1) - Spears | 1-6 7-5 6-2 |
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| Troy $50,000 Hard | Oct 17 2010 |
| 1 | Spears - Grace Min | 6-1 6-4 |
| 2 | Lindsay Lee-Waters(6) - Spears | 6-4 6-4 |
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| Rock Hill $25,000 Hard | Oct 24 2010 |
| 1 | Johanna Konta - Spears(7) | 3-6 6-4 6-2 |
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| Grapevine $50,000 Hard | Nov 7 2010 |
| 1 | Spears - Grace Min | 6-2 6-0 |
| 2 | Jamie Hampton(6) - Spears | 6-1 7-5 |